Generation of MHC class II–peptide ligands for CD4 T-cell allorecognition of MHC class II molecules

Structural Properties of MHC Class II Ligands, Implications for the Prediction of MHC Class II Epitopes

Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, allowing binding of peptides extending out of the binding groove. Furthermore, only a few HLA-DR all...

CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells.

The role of B lymphocytes in initiating and maintaining a CD4+ T cell response has been examined using a variety of strategies, but remains controversial because of weaknesses inherent to each of the approaches. Here, we address this issue by measuring CD4+ T cell priming both in mutant mice devoid of B cells and in chimeric animals lacking major histocompatibility complex class II molecules sp...

Self-Specific MHC Class II-Restricted CD4

Superantigen and class II MHC molecules.

Class II Molecules Determines the Intracellular Fate of MHC Class II Molecules and Bound Peptide Hydrogen Bond Integrity Between MHC